Regarding SQL server db while upgrading SEPM RU5 to RU6

Hi,

My SEPM db server (MSSQL server) is having connection with two more database server which are replicating the sepm db. So do i need to disconnect all outside db connections before upgrading SEPM RU5 to RU6. i am having sepm application and sql server on the same machine. also tell me the procedure to disconnect the outside connection to sepm db.

Thanks